CRB capitalized on its ONEsolution project approach to fast-track this 60,000-square-foot manufacturing facility with future expansions in mind. Our approach was instrumental in the facility winning the highly coveted ISPE Facility of the Year Award.

CRB partnered with BioNTech and leveraged experience, expertise and knowledge of Current Good Manufacturing Practices (CGMP) to drive efficiencies, incorporate new technologies and align with an evolving regulatory framework that defines Messenger RNA (mRNA) as an Advanced Therapy Medicinal Product (ATMP). The project demanded a flexible solution – adaptable in a dynamic environment, while providing cost-effective medicine for patients.

CRB’s operations improvement study resulted in optimized facility space and increased sample throughput by 49% while the new facility was under construction.

CRB deployed our ONEsolution project delivery model to transform an existing 48,000-square-foot warehouse into an inviting, flexible and efficient space for this new bioanalytical lab.

COVID-19 redefined risk for projects across the life sciences industry. As our clients worked to develop therapies and vaccines for SARS-CoV-2, CRB worked alongside them to design an expandable facility to enable the clinical work and commercial-scale production of life-saving products. We designed a flexible and adaptable space for quick design approval and long-lead equipment packages to produce a vaccine in record time for this 2,100-square-meter COVID-19 mRNA vaccine production facility.

CRB delivered a 46,000-sqft, architecturally-stunning laboratory, office and amenity space located in the top two floors of a 14-story tower in downtown Philadelphia. Our design boasts BSL-2 labs coupled with creative mechanical and HVAC solutions, open collaborative areas, city views and green space to bring the outside in.

CRB used our ONEsolution project approach to quickly design and construct a new CGMP facility, CGMP warehouse, administrative, laboratory and support spaces, totaling 220,000-square-feet. We met the condensed timeline for this multi-product, multi-process facility, which was constructed in less than 12 months from project initiation.

Sustainable design and construction practices were the driving requirements for the client’s 86,000-square-foot headquarters and fermentation process plant.  Our sustainable solutions - delivered via ONEsolution - earned the facility the Sustainable Plant of the Year Award from Food Engineering magazine.

CRB designed this ambitious 174,000-square-foot project with flexibility, safety and scalability in mind, setting a new bar for product quality and safety in the pet treat industry. We brought our experience from human food production and biopharmaceutical manufacturing to the design, resulting in a 500% capacity increase for this innovation-driven, ultra-flexible pet treat manufacturing facility.

CRB implemented our ONEsolution project approach to design and construct a new 35,000-square-foot facility for this rapidly growing contract development and manufacturing organization (CDMO) to double production capacity for monoclonal antibody (mAb) drug substances. Our integrated delivery accelerated this biopharma expansion project to support the widest possible variety of CDMO clients, now and into the future. We designed new CGMP manufacturing trains, quality control labs and warehousing to be robust and flexible now and in the future.

CRB conducted an efficiency improvement study that reduced headcount by 40%, reduced procedures by more than 50% and produced an annual savings of $3.8 million site-wide - improving production operations, labor efficiency and reducing operating expenses.